Seperating the Components of Panacetin

Alex Wilson 9/11/12 Experiment 2 Separating the Components of Panacetin Introduction Of the terzetto components likely to be present in your stress of Panacetin ( acetylsalicylic acid, acetanilide, and starch), only starch is insoluble in the organic solvent dichloromethane (or methylene chloride), CH2 Cl2. If a sample of Panacetin is dissolved as completely as possible in dichloromethane, the insoluble starch can be filtered out, leaving acetanilide and acetylsalicylic acid in solution. The take of this experiment is to extract the components of Panacetin.Although the acetanilide and aspirin are both quite insoluble in water at room temperature, the atomic number 11 salt of aspirin is very soluble in water but insoluble in dichloromethane. Because aspirin is a reasonably strong acid, it can be converted to the salt, sodium acetylsalicylate, by reaction with the basic sodium hydroxide. While the two stratums are thoroughly mixed, the aspirin allow react with the sodium hydroxi de in the privy layer, which then migrates to the aqueous layer and can be easily separated in a separatory funnel.Adding some dilute hydrochloric acid to the aqueous solution restores let go of aspirin as an insoluble white solid evaporating the solvent from the bottom layer leaves the acetanilide behind. Experimental For the separation of sucrose, we weighed out 3. 048g of Panacetin onto a filter, and 50 mL of dichloromethane in a graduated cylinder. Then we transferred both the panacetin and dichloromethane into an Erlenmeyer flask and stirred it until the panacetin was dissolved. We let it dry by gravity and set it excursus to dry. The filter paper weighed about 1. 320g and sucrose weighed out at 1. 028g.saccharose also ended up on the outside rim of the filter paper. We then last to separate the aspirin. We measured 30mL of NaHCO3 and mixed it with 7mL of 6M HCl. We drained the organic layer into a pre-weighed Erlenmeyer flask and save it for recovery of acetanilide. We to ok the combined aqueous extracts in an Erlenmeyer flask, and acidify the aqueous solution by slow addition, with stirring, of 20 mL of 6M HCl. We made sure the solution is strongly acidic by testing it with litmus paper acquire a pH of 2. We then cooled the mixture to room temperature swirling the flask occasionally in an ice bath.We collected the aspirin by vacuum filtration and washed the aspirin on the filter with cold distilled water. We let it air dry for 30-35 minutes and then weighed the aspirin. It weighed out at 0. 513g. The unknown component was calculated and weighed at 0. 738g. Results When we were coalesce the filtration and letting it vent periodically, we lost some of it. So our percent recovery is as follows The unknown component weighed 0. 738g. And our percent composition is as follows Discussion Sucrose is insoluble in the organic solvent dichloromethane (CH2 Cl2). acetylsalicylic acid, acetanilide, and phenacetin are soluble in dichloromethane but relatively so luble in water. Aspirin reacts with bases such as sodium bicarbonate to form a salt, sodium acetylsalicylate, which is insoluble in water. Acetanilide and phenacetin are not converted into salts by sodium bicarbonate. The Reciprocal (Interconversion) of Aspirin and its Sodium Salt Conclusion The breakdown of Panacetin Mix panacetin with CH2 Cl2 and you will remove a solid which is sucrose and youll get a filtrate of aspirin and an unknown substance. Then you will extract the aspirin with NaHCO3 to get an organic layer and a water layer.The bottom layer for us was the organic layer, while the top layer was the water layer. After figuring out the organic layer you mix the unknown with CH2 Cl2, and then you will evaporate to leave just the unknown substance. When you figure out which layer was the water layer, youll mix sodium salicylate and H2O. You will then add HCl until the pH direct of the solution reaches 2. After the pH reaces2, you have aspirin which proves that as long as yo u follow the directions in this lab, you will have indeed separated the aspirin from the panacetin.